1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling

1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling

Blog Article

Naphthoquinones may cause oxidative stress in exposed cells and, Hay bags therefore, affect redox signaling.Here, contributions of redox cycling and alkylating properties of quinones (both natural and synthetic, such as plumbagin, juglone, lawsone, menadione, methoxy-naphthoquinones, and others) to cellular and inter-cellular signaling processes are discussed: (i) naphthoquinone-induced Nrf2-dependent modulation of gene expression and its potentially beneficial Queen Storage Headboard outcome; (ii) the modulation of receptor tyrosine kinases, such as the epidermal growth factor receptor by naphthoquinones, resulting in altered gap junctional intercellular communication.Generation of reactive oxygen species and modulation of redox signaling are properties of naphthoquinones that render them interesting leads for the development of novel compounds of potential use in various therapeutic settings.